Flu Drug Tamiflu No Longer Effective against Flu Strain; Other Combinations Available
Physicians treating patients presenting with influenza should know that the dominant strain of flu circulating in the United States has become resistant to the antiviral medication Tamiflu (oseltamivir), the most commonly used drug for treating patients diagnosed as having the flu, according to a February 23, 2009, article posted online at AMNews . In fact, 98% of the A virus (H1H1) currently circulating in the United States is resistant to the antiviral drug, the article states. According to the Centers for Disease Control and Prevention (CDC), while influenza activity is currently low, the rate is expected to increase over the next several months, and physicians should be aware of other drugs or drug combinations available for treatment. Interim CDC recommendations, which stress the need for physicians to continue prevention efforts through immunizations, include combining the use of oseltamivir, which is a neuraminidase inhibitor, and Flumadine (rimantadine), which is an adamantine, for infected patients. Another approved antiviral drug in the United States is amantadine. Additional recommendations include using Relenza (zanamivir), which is also effective against the virus; however, young children and those prone to wheezing should not use the inhaled medication. Officials are concerned about the developing resistance to Tamiflu, according to the article, because the U.S. federal government has been stockpiling the drug in the event of a pandemic flu outbreak. According to CDC's Influenza Division, the antiviral resistance has emerged over the past two years despite the fact that the medication has not been overused.
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